Circular RNA Expression: Its Potential Regulation and Function
نویسندگان
چکیده
منابع مشابه
Potential role of hsa_circ_0003098 circular RNA in breast cancer and its association with demographic factors and lymph node metastasis
Background and Objectives: A growing amount of evidence has revealed that circular RNAs (circRNAs), covalently closed single-stranded non-coding RNAs (ncRNAs), play significant roles in initiation and progression of breast cancer (BC) through different mechanisms. This study aims to investigate the hsa_circ_0003098 expression and its potential roles in BC, as well as the circRNA/miRNA/mRNA cro...
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Objective To assess the circular RNAs (circRNAs) expression profile and explore the potential functions in human thoracic aortic dissection (TAD). Methods The differentially expressed circRNAs profiles of the aortic segments between human type A TAD patients (n=3) and age-matched normal donors (NA; n=3) were analyzed using the Arraystar human circRNAs microarray. Quantitative real-time PCR wa...
متن کاملCircular RNAs: analysis, expression and potential functions.
Just a few years ago, it had been assumed that the dominant RNA isoforms produced from eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene expression. In early 2012, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RN...
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OBJECTIVES Recent studies have demonstrated the role of Cdr1as (or CiRS-7), one of the well-identified circular RNAs (circRNAs), as a miR-7a/b sponge or inhibitor in brain tissues or islet cells. This study aimed to investigate the presence of Cdr1as/miR-7a pathway in cardiomyocytes, and explore the mechanism underlying the function of miR-7a in protecting against myocardial infarction (MI)-ind...
متن کاملGlobal circular RNA expression profile of human gastric cancer and its clinical significance
Circular RNAs (circRNAs) are a new class of noncoding RNAs. However, the expression profile and clinical significance of circRNAs in human gastric cancer is unclear. The global circRNA expression profile in human gastric cancer was measured by circRNA microarray. Hsa_circ_0014717, one of the most downregulated circRNAs in microarray, was selected as a targeted circRNA to explore its levels in g...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2016
ISSN: 0168-9525
DOI: 10.1016/j.tig.2016.03.002